DNA Damage and Aging of the Corneal Endothelium

Corneal endothelium (CE) is the posterior tissue layer of the cornea and is critical for maintenance of corneal hydration and transparency.
Aging, UV light from sun exposure, or some drugs used in refractive surgery contribute to DNA damage in the CE.
This project examines the roles of cell-cell communications in the CE response to DNA damage with the goals of preserving CE function in corneas compromised by natural aging or other cellular stressors.

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