"In-Situ Display of Optical Coherence Tomography within the Stereomicroscope for Guiding Microsurgery"

October 3, 2012 -
11:45am to 1:00pm

The Fox Center for Vision Restoration organizes an exciting lecture series focusing on ocular regeneration and new therapies.

Distinguished national and international speakers present their innovative and multidisciplinary approaches to finding cures for vision impairment. The objective of this lecture series is to accelerate research through knowledge sharing, partnership building and out of the box thinking.

John Galleotti, PhDJohn Galleotti
Senior Project Scientist, Robotics Institute, Carnegie Mellon University
October 3, 11:45am – 1:00pm
(Please RSVP to baurothr@upmc.edu)

Dr. Galleotti earned his bachelor's and master's degrees from North Carolina State University, Department of Electrical and Computer Engineering. He then studied under Dr. George Stetton at Carnegie Mellon University Robotics Institute, where he earned his PhD, focusing on Medical Imaging and Holographic Visualization.

Dr. Galleotti's research focuses on artificial intelligence and computer vision, especially as applied to medical/bio-robotics. He helped develop his lab's "Shells and Spheres" variable-scale statistical framework for n-dimensional image analysis, and he is working on novel extensions of the project, which promise to produce more effective and efficient algorithms. More information.

Presentation abstract

We have developed a new image-based guidance system for microsurgery using optical coherence tomography (OCT), which presents a continuously updated virtual image in its correct location inside the scanned tissue. OCT provides real-time high-resolution (3-6 micron) images at video rates within a two-or-more millimeter axial range in soft tissue, and is therefore suitable for guidance to various targets in the eye. Ophthalmologic applications in general are diverse within the realm of anterior-segment surgery, whether for medical treatment or for scientific experimentation. Surgical manipulations, especially of the cornea, limbus, and lens may eventually be aided or enabled, and as an example we are presently working to guide access to Schlemm’s canal for treating Glaucoma. Our current prototype produces virtual images with sufficient resolution and intensity to be useful under magnification, while the geometrical arrangement between the OCT scanner and display optics (including a half-silvered mirror) permits sufficient surgical access. We have constructed two prototypes thus far, with the first using a miniature organic light emitting diode (OLED) display and the second using a reflective liquid crystal on silicon (LCoS) display. The OLED has the advantage of relative simplicity, satisfactory resolution (15 micron), and color capability, whereas the LCoS can produce an image with much higher intensity and superior resolution (12 micron), although it is monochromatic and more complicated optically. Intensity is a crucial limiting factor, since light flux is greatly diminished with increasing magnification, thus favoring the LCoS approach as more practical for use with a stereomicroscope (4x magnification and greater).