"A Regenerative Medicine Approach for Optic Nerve Reconstruction Using Biologic Scaffold Materials"

November 3, 2010 -
11:45am to 1:00pm

OTERO Optic Nerve

The Fox Center for Vision Restoration launches an exciting lecture series focusing on ocular regeneration and new therapies.

Distinguished national and international speakers will present their innovative and multidisciplinary approaches to finding cures for vision impairment. The objective of this lecture series is to accelerate research through knowledge sharing, partnership building and out of the box thinking.

Dr. Stephen Badylak and Dr. Peter Crapo

Stephen BadylakDr. Stephen Badylak
Dr. Badylak is Professor in the Department of Surgery at the University of Pittsburgh as well as Deputy Director of the McGowan Institute for Regenerative Medicine and Director of the McGowan Center for Preclinical Studies.
Dr. Badylak’s laboratory is a highly interdisciplinary environment. The major focus of the laboratory is the development of regenerative medicine strategies for tissue and organ replacement.  The use of mammalian extracellular matrix (ECM) or its derivatives as an inductive template for constructive remodeling of tissue is a common theme of most research activities. The goal of all projects is clinical translation and improved patient care.

Peter Crapo Dr. Peter Crapo
Dr. Peter Crapo is a Postdoctoral Fellow in the OTERO Program. The OTERO Program (Ocular Tissue Engineering and Regenerative Ophthalmology) aims to restore sight through regenerative medicine based strategies.

Dr. Crapo's primary focus is the development of biologic scaffolds for optic nerve repair and vision restoration.

Abstract of the Presentation

"A Regenerative Medicine Approach for Optic Nerve Reconstruction Using Biologic Scaffold Materials"
Diseases that injure the optic nerve such as glaucoma and optic neuritis affect millions worldwide and have a substantial negative impact on quality of life for affected individuals as they cope with vision loss and blindness. Optic nerve damage is irreversible and current clinical treatments focus on prevention due to the limited regenerative capacity of the mammalian central nervous system.
Drs. Badylak and Crapo Decellularized xenogeneic tissues have been used both clinically and in preclinical studies as biologic scaffolds that facilitate the constructive remodeling of a variety of tissues, including skin, muscle, tendon, bladder, esophagus, and various connective tissues rather than scar tissue formation. There is evidence for tissue-specificity in biologic scaffold-mediated wound repair, indicating that neural-derived biologic scaffolds may be advantageous for optic nerve repair.
This presentation will focus on the development of biologic scaffolds from neural tissues such as the optic nerve, spinal cord, and brain and the investigation of their material properties.
Initial studies have included the in vitro effects of neural biologic scaffolds on several cell types that may be critical to constructive remodeling of the central nervous system, including human neural stem cells from the cortex and spinal cord and human perivascular stem cells, as well as a commonly used rat neural cell line derived from adrenal pheochromocytoma, PC12 cells. Studies to date include the effects of neural biologic scaffolds on cell viability, proliferation, and migration.

Location and Address

Eye and Ear Boardroom, 5th floor, Eye and Ear Institute
203 Lothrop Street, Pittsburgh PA 15213