"Drag-Reducing Polymer Effects on Blood Microcirculation In Vivo and In Vitro"

January 5, 2011 -
11:45am to 1:00pm

Marina Kameneva, PhDMarina Kameneva

Presentation abstract

Drag-reducing polymers (DRPs) are soluble long-chain polymers with a molecular mass above1000 kDa and fairly linear molecular structure that have been discovered to significantly reduce resistance in a fully developed turbulent flow in pipes when added to the flowing fluid at minute concentrations (Toms effect).

Though the flow conditions associated with the Toms phenomenon do not occur when blood flows through the vascular system, a number of studies have shown that intravenous administration of DRPs to experimental animals produce significant beneficial effects on blood circulation increasing blood flow, tissue perfusion, tissue oxygenation and decreasing peripheral vascular resistance.

This presentation will review major results obtained in various pre-clinical models and in vitro tests which employed DRPs as blood additives. Furthermore, the potential mechanisms behind the DRP phenomena in blood circulation in vivo including their effects on the traffic of RBC in microvessels will be discussed.
Dr. Kameneva is Research Professor of Surgery and Bioengineering and Director, Hemorheology, Hemodynamics and Artificial Blood Research Laboratory at the McGowan Institute for Regenerative Medicine.

Dr. Marina V. Kameneva’s Hemorheology, Hemodynamics and Artificial Blood Research Laboratory is working on a variety of projects ranging from the testing of new medical devices to performing theoretical and experimental research related to the development of next generation artificial organs including artificial blood.
 

Location and Address

Eye and Ear Institute
5th floor Boardroom
203 Lothrop Street
Pittsburgh, PA 15213